DAILY UPDATE: Moderna Down with Mixed Markets

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Here’s where the major benchmarks ended:

  • The S&P 500® index (SPX) fell 1.26 points (0.02%) to 5,221.42; the Dow Jones Industrial Average lost 81.33 points (0.2%) to 39,431.51; the NASDAQ Composite® ($COMP) gained 47.37 points (0.3%) to 16,388.24.
  • The 10-year Treasury note yield (TNX) dropped almost 2 basis points to 4.487%.
  • The CBOE Volatility Index® (VIX) surged 1.05 to 13.60.

Biotechnology and food and beverage shares were among the market’s strongest sectors Monday, while communication services stocks were among the biggest laggards. Energy shares took pressure despite a jump of 1.2% in WTI Crude Oil (/CL) futures, which ended above $79 per barrel after slumping last week to two-month lows.

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Moderna is “bleeding money” as its forthcoming RSV vaccine doesn’t appear to deliver better results than other RSV shots already on the market. (Bloomberg)

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It’s ChatGPT-4o’s time to shine. The “o” stands for omni, and it’s the latest iteration of OpenAI’s signature chatbot. According to the company, it’s much faster with enhanced “capabilities across text, vision, and audio.”

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23% is the average portion of the bill hospitals collected from patients before treatment in Q1 of this year, up 3% YoY. (the Wall Street Journal)

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DAILY UPDATE: New CDC Covid-19 Guidelines as the Stock Markets Go Lower

By Staff Reporters

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The CDC may update Covid-19 isolation guidelines from five days to 24 hours if an individual is fever-free without medication—standardizing the protocol for the disease with the same rule for the flu and RSV. (the New York Times)

Here’s where the major benchmarks ended:

Stocks slumped into the long weekend yesterday, snapping a five-week weekly winning streak when they fell in the wake of wholesale price data that shows inflation is probably not as tamed as the Fed would like it to be. But Coinbase gave the latest indication that the crypto winter has thawed. The crypto exchange’s stock rose after it reported its first quarterly profit in two years.

  • The S&P 500 index fell 24.16 points (0.5%) to 5,005.57, down 0.4% for the week; the Dow Jones Industrial Average® (DJI) lost 145.13 points (0.4%) to 38,627.99, down 0.1% for the week; the NASDAQ Composite® (COMP) declined 130.52 points (0.8%) to 15,775.65, down 1.3% for the week.
  • The 10-year Treasury note yield (TNX) rose over 4 basis points to 4.285%.
  • The CBOE Volatility Index® (VIX) rose 0.23 to 14.24.

Communications services and transportation shares were among the market’s weakest performers Friday, while energy companies firmed behind strength in crude oil futures. The small-cap Russell 2000® Index (RUT) fell 1.4% Friday but still ended the week with a gain of 1.1%, its second straight weekly advance.

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2023 NOBEL PRIZE: MEDICINE Katalin Karikó and Drew Weissman PHYSICS Pierre Agostini, Ferenc Krausz and Anne L’Huillier

MEDICINE: By Staff Reporters

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Dr. Katalin Karikó and Drew Weissman MD PhD just received the Nobel Prize in medicine. Their study of mRNA led to the development of the Covid-19 vaccine.

Oiginally from Hungary, Kariko joined the University of Pennsylvania as a research assistant professor in 1989 to study mRNA. Her grant proposals were constantly rejected, while the rest of the scientific community was slow to catch on to her groundbreaking research. She was never paid more than $60,000 a year. And it was only through a chance encounter at the photocopier that she began to work with Weissman, currently the director of the Penn Institute for RNA Innovation.

The two made the discovery of a lifetime in 2005—that mRNA can be manipulated and injected into the body to activate an immune response. The major academic journals Science and Nature rejected their paper, which received little fanfare even after being published in a less prestigious journal.

So, in 2013, Karikó left Penn for a job at BioNTech where she still works today. And, of course, their breakthrough came in handy during the global pandemic.

Thanks largely to Karikó and Weissman, mRNA vaccine technology, Moderna and BioNTech are working on mRNA vaccines for RSV, HIV, Zika, malaria, shingles, flu, and cancer.

RSV Tests: https://medicalexecutivepost.com/2023/09/25/rsv-vaccine-cdc-oks-pfizer-maternal-shots/

DNA: Testing: https://wordpress.com/post/medicalexecutivepost.com/395273

DANGER: DNA Self-Testing: https://medicalexecutivepost.com/2021/04/25/the-potential-dangers-of-testing-your-own-dna/

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PHYSICS: By Staff Reporters

And, three scientists won the Nobel Prize in physics yesterday for their work on how electrons move around the atom during the tiniest fractions of seconds, a field that could one day lead to better electronics or disease diagnoses.

The award went to Pierre Agostini, Ferenc Krausz and Anne L’Huillier for their study of the tiny part of each atom that races around the center and that is fundamental to virtually everything: chemistry, physics, our bodies and our gadgets.

The movements of electrons inside atoms and molecules are so rapid that they are measured in attoseconds – an almost incomprehensibly short unit of time. “An attosecond is to one second as one second is to the age of the universe,” the committee explained.

“They were able to, in a sense, provide an illumination tool that allows us to watch the assembly of molecules: how things come together to make a molecule,” Bob Rosner, president of the American Physical Society and a professor at the University of Chicago, told CNN.

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RSV VACCINE: CDC OK’s Pfizer Maternal Shots

By Staff Reporters

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Respiratory syncytial virus (RSV), also called human respiratory syncytial virus (hRSV) and human orthopneumovirus, is a common, contagious virus that causes infections of the respiratory tract. It is a negative-sense, single-stranded RNA virus. Its name is derived from the large cells known as syncytia that form when infected cells fuse.

CITE: https://www.r2library.com/Resource

CDC panel backs Pfizer’s maternal RSV vaccine

A Centers for Disease Control and Prevention advisory committee yesterday recommended administering the vaccine to pregnant people during the third trimester to prevent infants from contracting the virus.

The vaccine is already available, and another RSV vaccine made by AstraZeneca and Sanofi, which is given directly to babies, also won approval recently. RSV sends ~80,000 children under five to US hospitals annually, according to the CDC, and it’s the second leading cause of death for under-one-year-olds globally.

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PUBLIC HEALTH: RSV versus COVID?

[Emergency Request]

By Staff Reporters

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Children’s hospitals are asking the federal government to declare a public health emergency to help them deal with the surge of RSV cases. Infants are being hospitalized at seven times the rate of 2018.

DEFINITION: Respiratory syncytial virus, also called human respiratory syncytial virus and human orthopneumovirus, is a common, contagious airborne virus that causes infections of the respiratory tract. It is a negative-sense, single-stranded RNA virus.

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