DAILY UPDATE: Human Genome Project as the Dow and NASDAQ Diverge

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CITE: https://www.r2library.com/Resource

When it comes to scientific achievements that have advanced the practice of medicine, you’d be hard-pressed to find one more influential than the Human Genome Project. The project, a federally funded collaboration between scientists around the globe, began in October 1990 with the goal of improving our knowledge of human biology by sequencing an entire human genome, which is the complete set of DNA in a cell. Nearly 13 years and $2.7 billion later, the project wrapped up in April 2003, and scientists around the world now use the reference human genome to study genetics, biology, and more. Today, the entire human genome can be sequenced in as little as five hours and costs as little as $600. Learn more about the Human Genome Project’s impact here.

CITE: https://tinyurl.com/2h47urt5

🟢 What’s up

  • Jack in the Box popped like a…well, you know…after activist investor Biglari Capital reportedly accrued a 10% stake in the fast-food company. Shares rose 7.86%.
  • Robinhood Markets climbed 6.12% on speculation that it may be added to the S&P 500 to fill the spot left by Juniper Networks.
  • Rigetti Computing rose 15.45% after Cantor Fitzgerald analysts initiated their coverage of the quantum computing company with an “overweight” rating.
  • Verint Systems jumped 15.33% on reports that the customer service software maker may be acquired by Thoma Bravo.
  • Corona parent company Constellation Brands gained 4.48% after it reiterated its fiscal guidance, assuring shareholders that aluminum tariffs will only cost the company about $20 million.
  • Crypto companies gained across the board after bitcoin miner BitMine Immersion Technologies announced it’s pivoting to ethereum. BitMine rose 21.17%, MARA Holdings gained 13.38%, and CleanSpark climbed 12.64%.

What’s down

  • Centene plunged 40.37% after the health insurer rescinded its fiscal 2025 guidance, warning that EPS will come in lower than anticipated.
  • Centene’s news pulled the rest of the health insurance industry down with it. UnitedHealth Group lost 5.70%, CVS Health fell 4.28%, Elevance Health stumbled 11.50%, and Molina Healthcare dropped 21.97%.
  • Paramount Global sank 2.43% after the company settled its 60 Minutes lawsuit with President Trump for $16 million.
  • Marvell Technology slipped 2.61% on reports that Microsoft is cutting back on manufacturing AI chips in-house.
  • Intel lost 4.25% on the news that it may be shifting the strategy behind its foundry business.

CITE: https://tinyurl.com/tj8smmes

Visualize: How private equity tangled banks in a web of debt, from the Financial Times.

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On CRISPR Gene Editing

DEFINITION: CRISPR is a family of DNA sequences found in the genomes of prokaryotic organisms such as bacteria and archaea. These sequences are derived from DNA fragments of bacteriophages that had previously infected the prokaryote. They are used to detect and destroy DNA from similar bacteriophages during subsequent infections

CITE: https://www.amazon.com/Dictionary-Health-Information-Technology-Security/dp/0826149952/ref=sr_1_5?ie=UTF8&s=books&qid=1254413315&sr=1-5

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A Gene Editing Breakthrough
For the first time, CRISPR technology has been used to successfully treat disease in vivo, or inside the human body.

That big medical news was announced Saturday by the biotech startup Intellia Therapeutics and its partner Regeneron, which said their gene-editing techniques reduced the amount of harmful liver protein associated with a genetic nerve disorder. 

What is CRISPR? It stands for “clustered regularly interspaced short palindromic repeats,” and it’s one of those things humans found in nature and then copied.  Bacteria use CRISPR to repel viruses, but humans have harnessed it to ctrl+c, ctrl+v DNA sequences, potentially leading to a revolution in treating disease.  The two scientists who made that breakthrough in 2012, Jennifer Doudna and Emmanuelle Charpentier, won the Nobel Prize in Chemistry last year (Doudna is also a cofounder of Intellia).

Quote du jour: “There’s a feeling like we’re walking through a door here into all kinds of new possibilities. And there’s not many moments in medicine where you get to experience that,” Intellia CEO John Leonard said.  Looking ahead…expect Intellia shares, which have gained 233% since its 2016 IPO, to pop.

CRISPR/Cas9 Genome Editing Technique - Musicians4Freedom

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